Archive for cortisol
Hypothyroidism, or slowing of the thyroid, is a common problem as women age.
Many women develop this condition prior to the onset of the menopausal transition. The effects of aging on hormones can precipitate this condition and it is important for you to talk with your medical provider about testing for this if you are experiencing excessive fatigue.
The thyroid gland is located at the base of the neck and is responsible for the rate at which your body systems function. Symptoms of hypothyroidism include:
- dry skin
- slowing of mental functions or difficulty thinking
- hair loss
- feeling cold
These are a few of the symptoms, there are many biological changes which occur that can be measured or evaluated by your provider. The reverse condition, called hyperthyroidism, is much less common and is not as associated with aging.
The thyroid gland produces the hormones, T3 and T4. This is regulated by the pituitary gland through production of TSH (thyroid stimulating hormone). The regulation of thyroid function in the pituitary gland(in the brain) is in turn regulated by the hypothalamus (also in the brain) by production of thyrotropin releasing hormone. It is through the action of elevated cortisol that this finely tuned system is altered.
Prolonged stress and the resulting production of CRH ( corticotropin releasing hormone) causes prolonged elevated amounts of cortisol. This in turn inhibits TSH production and secretion. The elevated levels of cortisol in the blood stream also inhibit conversion of the thyroid hormone T4 to T3. Our bodies need both forms of this thyroid hormone to function normally. T3 is produced in lower quantities but is 4 times more powerful than T4.
This could be the cause of what is termed the “sick euthyroid” syndrome. In this setting, people have all the symptoms of hypothyroidism but their thyroid lab work is normal. Some people can have difficulty converting T4 to T3 due to lack of an enzyme. So let’s put this together.
If you are a person who is genetically susceptible to these conditions, and you are entering peri menopause without a very healthy lifestyle. You are having trouble sleeping, your life is stressed and you are taking no time for yourself. You eat convenience food because you don’t have the time or energy to exercise and plan detailed meals. So your cortisol levels go up and you start gaining weight. Then it all spirals downward with more fatigue because your thyroid is not working well. What can you do to stop this?
Most of our previous posts have dealt with this very issue.
Important lifestyle changes to consider:
- eat a diet low in processed foods, sugars and saturated fat
- limit alcohol, caffeine, nicotine
- exercise and/or find ways to add physical activity into your daily routine
- practice techniques to lower stress
- sleep enough hours to allow you to feel rested; 7-9 hours nightly
- take vacation days periodically through the year
- laugh with friends and family
Speak with your provider about how you are feeling and what you would like to have checked medically. Voice your concerns so you are heard!
Tell us your story. What good or bad experiences have you had with fatigue and thyroid issues? Leave your story, questions or input in the comments section.
We have talked about cortisol in prior posts, and many of you may be wondering why this particular
hormone is so important during menopause. We often think the cause of all our problems is from low estrogen. This is only part of the reason for your symptoms.
Cortisol is the stress hormone that we need when our bodies are under stress.The problem comes when our bodies have been under prolonged stress such as caused by hectic lives lacking adequate sleep and relaxation.
- Cortisol increases heart rate,
- slows digestion,
- slows cell repair and regeneration,
- breaks down healthy muscle and bone
- weakens the immune system.
This increase in cortisol can wreck havoc on the balance of the different hormones that has been maintained. The falling estrogen levels also contribute to the stress response, as estrogen is involved in many functions within the body.
Cortisol is produced in the adrenal glands along with other hormones such as progesterone, some forms of estrogen, adrenaline, and testosterone. These hormones all come from the same parent hormones. What this means is that one hormone can be produced in excess at the expense of other hormones. When the body is under stress, the adrenals will cause the progesterone to be broken down to cortisol alone which leads to a reduction of DHEA (parent compound of estrogen and testosterone).
This cortisol then helps the liver to produce glucose because the body is anticipating the need for action and is providing the energy for this. In our modern day world, this kind of physical action rarely occurs, so what happens to all that excess glucose (sugar)? You guessed it, it is stored as fat. Usually visceral fat.
The adrenals also play a role in attempting to maintain estrogen levels as the ovaries are declining in function. The elevated cortisol levels will cause visceral fat to be made and stored in the abdomen. This visceral fat produces estrone, which is a form of estrogen. The adrenals produce estrone and belly fat produces estrone. This may very well be why all of a sudden, around the time of menopause, you have belly fat (or more belly fat)!
The adrenals do not act on their own, they have help from the brain. The brain, specifically the hypothalamus and pituitary, are the master controllers of our endocrine functions. Without these areas controlling and regulating, the separate organs may produce too much or too little of whatever hormone they are responsible for. During stress, the brain is attempting to reduce reproductive capacity, growth and thyroid function. This is done to help with survival. In this country and in this day and age, we are rarely in a position of having our very survival threatened. So the stress of our lives are unnecessarily causing all these problems.
So what do you do?
Reduce stress, reduce stress, reduce stress. This will reduce cortisol, which will hopefully reduce visceral fat production and reduce glucose production. This in turn will reduce heart disease, insulin resistance, and improve endocrine function of the non-stress hormones produced in the adrenals.
Reduce stress in a way that is enjoyable to you. Therefore you will be likely to make this part of your daily routine. Exercise, mediation, yoga. You must get adequate sleep, at least 7 hours a night. Your diet is important also, reduce sugar, alcohol, caffeine as these items can contribute to elevated cortisol levels.
Start with little changes, pick one new thing you will do and do it daily for a few weeks. When that is a common practice for you, pick another item you want to change. Change can be slow, this is often the more effective way to make changes that stick.
Write in the comments section and tell us your stories on changes you have made. Your story will most likely help and inspire someone else to make a change!
Fatigue is one of the most common problems that women voice as they are moving through the menopausal transition. We have discussed in previous posts the causes of fatigue in peri and post menopausal women. The reasons can be numerous and multifaceted.
The commonly thought of causes include sleep disturbance from hot flashes, restless leg syndrome and obstructive sleep apnea.
Women can become anemic from irregular and heavy menses in peri-menopause, this can certainly cause fatigue.
Often times women on are medication to treat disorders and diseases, and these medications can cause fatigue.
Thyroid disorders can cause fatigue, as the thyroid hormones are responsible for setting our metabolic rate (the rate at which our bodily functions work).
Lastly, depression and anxiety can cause fatigue mostly through the chemicals in our brain not being in enough supply or in the correct proportion.
Let’s talk about hormones and how they can affect fatigue. The steroid hormones are hormones produced for an action, production is stimulated by the brain, and they are meant for immediate use by the body. The hormones I will discuss are produced in both the ovaries and the adrenal glands. The hormones that are primarily responsible for the change in how you feel during menopause are:
- thyroid hormone T3 and T4
Cholesterol is the precursor for all of these hormones with the exception of thyroid hormones. Cholesterol is broken down into basically 2 parent compounds which then go through changes to become the above list with the exception of thyroid hormones.
One parent compound, pregnenolole eventually becomes
- cortisol and
The other parent compound becomes Adrostenedione which eventually becomes
Why is this important for me to know?
Because knowledge is power. Once you understand what might be going on, you can decide to make changes to help relieve yourself of some of the symptoms you are experiencing.
Pre-menopausal, the production of these important hormones takes place in 2 places, your ovaries and your adrenal glands. Estrogen and progesterone in the ovaries and also in the adrenal glands, the rest are produced by the adrenals.
The adrenals are small organs which sit atop the kidneys. When the ovaries stop working, the production of progesterone starts a slow steady decline. The estrogen level falls rapidly but can also rise as the ovaries sputter along.
Many symptoms of bloating, fatigue and mood disturbance can be linked to not enough progesterone early in peri-menopause. While hot flashes, brain fog and fatigue can be linked to fluctuating and then low levels of estrogen. Prior to menopause, healthy estrogen levels help the action of cortisol which also helps to prevent cortisol excess. When estrogen falls, it leaves the cortisol unopposed and therefor in excess.
Why is excess cortisol bad?
Excess amounts of cortisol for prolonged periods of time can cause the following ill effects:
- weaken the immune system
- slow healing and normal cell repair
- impair digestion
- break down healthy muscle and bone
- interfere with the normal function of other hormones
- interfere with sleep
- increase appetite
Cortisol is a very important hormone when it is needed for immediate action or a stress response. Today’s stressful lifestyles can cause prolonged increase levels of cortisol and as a result, the above list of problems can occur.
So what can a person do to decrease the effects of hormonal changes and stress?
There is, of course, medication to treat the different symptoms. This you can discuss with your medical provider, it may mean you could be taking several different pills for all these different symptoms. What your medical provider may not have time to talk about are the lifestyle changes that can help all of this. (If you would like to talk to me about lifestyle changes, send me an email via out contact form. Click on the word contact on the black navigation bar at the top of this page.)
The following are all suggestions sited by the experts on how to change your lifestyle to help facilitate relief:
- decrease your stress response through measures such as yoga, meditation, prayer, anger management counseling, therapeutic massage
- exercise-this helps lower cortisol, lowers blood pressure, helps with stress, helps the cardiovascular system and your muscles remain healthy
- sleep-studies have shown people who get less than 4-5 hours of sleep are 72% more likely to be obese. This is due to hormones also
- a diet low in sugars and refined carbohydrates can lower the entire cascade of hormones which help to create obesity and elevated cortisol levels.
- a diet high in fresh vegetables and fruits, preferably produced locally so nutrients have not degraded, provides you with healthy anti-oxidants and other substances which the cells of our bodies utilize for healthy functions.
All this discussion of hormones and cortisol may seem mysterious and I will try to shed some light on the intricate interplay of these hormones in a future post. It is important to understand that you can change much of what is happening during menopause that is undesirable through your lifestyle.
It takes work and change and many people do not want to do this. The rewards of making changes and gaining some element of control over what is happening to your body can be very empowering. Every patient I have seen that successfully makes these changes have been immensely satisfied by the changes they have made. So ask yourself, what is stopping you from making the changes you know you should make?
I would like to hear from you in the comments section below. Things you can do are ask me
questions, tell me about your experiences, relate an epiphany you had or a way you have improved your energy. If you don’t want to do that, then share this with your friends on Facebook, Twitter or email by using one of the icons below.
Some people will be fat all their lives. It does not have to be that way. To be thin, they will have to have some help, but they will have to tell themselves they can do it. They will need some people around them saying the same thing. They will have to see themselves as OK despite being overweight. This slide show is an information tool. Anne and I want to be part of the support and accountability group for any woman who is in this situation over the age of 45.
When you want to be healthier and you are evaluating your health; consider these questions:
1. What is Insulin?
2. What are the “jobs” of Insulin?
3. How can I make my insulin more effective?
4. What am I possibly doing to make the effect of Insulin harmful to me?
The PDF from which these videos were made is available to download at the end of this post.
There were some vocabulary words used in the attached PDF and videos you may want to know more about.
Cortisol – best definition is near bottom of page
If you would like to learn more or get some personalized information use our contact page to send us a message.
Please remember, we are not your medical providers. If you are going to make changes to effect your health, be sure to check with your doctor first. It is a very good idea to have a relationship with a health care provider you trust who can advise you. We provide information only. Discuss this information with your health care provider.